SCIENTIFIC RESEARCH

Therapeutic strategies targeting miRNA and nutraceuticals for longevity

18.07.2024

Nutraceuticals and miRNA-mediated pathways influence ageing, with therapeutic strategies targeting these pathways to enhance healthspan and longevity. Diet and molecular interventions hold potential for promoting healthier ageing.

March 2024 – Frontiers in Aging

 

Key takeaways

 

  • Nutraceuticals can significantly influence ageing pathways and promote healthier ageing: Nutraceuticals, which include dietary supplements, functional foods, and herbal products, have bioactive compounds that can modulate ageing-related pathways. These compounds can reduce oxidative stress, inflammation, and cellular damage, which are key contributors to ageing, thus promoting healthier and more resilient body functions
  • miRNA-mediated pathways play a crucial role in regulating ageing processes: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. They are involved in various cellular processes, including those related to ageing. miRNAs can influence the expression of genes associated with longevity, stress responses, and metabolic pathways. Modulating miRNA activity can thus affect the ageing process and potentially extend lifespan
  • Targeting specific ageing pathways through therapeutic strategies can enhance healthspan and longevity: By identifying and targeting specific molecular and genetic pathways that influence ageing, researchers can develop therapies to slow down the ageing process. These therapeutic strategies might include drugs, gene therapies, or lifestyle interventions designed to modulate these pathways, ultimately aiming to prolong healthspan (the period of life spent in good health) and extend overall longevity
  • Dietary and molecular interventions hold promising potential for improving overall health during ageing: Interventions such as calorie restriction, specific nutrient supplementation, and molecular treatments targeting ageing-related pathways have shown potential in improving health outcomes in ageing populations. These interventions can enhance cellular repair mechanisms, reduce the incidence of age-related diseases, and improve overall quality of life as people age

 

Read the article at: Moochhala, Shirin H., et al. “Decoding the Secrets of Longevity: Unraveling Nutraceutical and miRNA-Mediated Aging Pathways and Therapeutic Strategies. Frontiers in Aging, vol. 5, 2024, article 1373741, https://doi.org/10.3389/fragi.2024.1373741

 

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