Daily multivitamin use slowed biological ageing by 10–20% over two years in older adults, as measured by advanced epigenetic clocks, suggesting a promising strategy to support healthy ageing when combined with good nutrition and lifestyle habits.
March 2025 – Medscape
Key takeaways
- Multivitamins slowed biological ageing: Older adults taking a daily multivitamin experienced 10–20% slower biological ageing over two years, based on epigenetic clock measurements. This suggests a meaningful impact on age-related processes at the molecular level and points to multivitamins as a potential tool for extending healthspan alongside lifestyle optimisation
- Greater benefits for high-risk individuals: Participants who showed signs of accelerated ageing at the start of the study gained the most from multivitamin use. This highlights the potential of targeted supplementation to help mitigate faster biological ageing in individuals who may be more vulnerable to age-related decline
- Second-generation clocks showed strongest effects: Among five types of epigenetic clocks used, the most significant slowing of ageing was detected by the second-generation clocks, PCGrimAge and PCPhenoAge. These tools are considered more accurate in predicting ageing-related health outcomes, reinforcing the reliability of the observed effects
- Not a substitute for healthy living: While the findings are promising, the researchers emphasise that multivitamins should complement—not replace—a healthy diet and lifestyle. Proper nutrition, physical activity, and overall wellness practices remain foundational for preventing chronic diseases of ageing and supporting long-term vitality
Read the article at: Manson, JoAnn E. “Multivitamins Slow Biological Aging in Large Trial.” Medscape, 2025, https://www.medscape.com/viewarticle/multivitamins-slow-biological-aging-large-trial-2025a10006u7.
