Aminoglycoside antibiotics, such as streptomycin, can inhibit TRP channels, disrupting calcium signalling essential for muscle and adipose tissue development. This interference may impair metabolic balance, potentially affecting healthspan and longevity.
July 2024 – Cells
Key Takeaways
- TRP channel inhibition by aminoglycosides affects cellular calcium signalling, which is vital for maintaining tissue health and metabolic processes: Aminoglycoside antibiotics, such as streptomycin, can block TRP channels, crucial components in cellular signalling. These channels regulate calcium levels, which play an essential role in processes like cell growth, repair, and communication. Disruption of this system could impair overall cellular function, with implications for health and ageing
- Muscle and adipose tissue development may be compromised, potentially impacting physical function and metabolic balance as we age: Calcium signalling influences the formation and maintenance of muscle and fat tissues. Interference with TRP channels may hinder these processes, leading to reduced muscle mass or altered fat storage. This can weaken physical resilience and disrupt energy regulation, both critical for healthy ageing
- Disruption of calcium homeostasis may lead to long-term metabolic imbalances, influencing healthspan and ageing outcomes: Calcium homeostasis ensures the stability of metabolic pathways that sustain energy production and cellular repair. Persistent interference with this balance can result in metabolic disorders, increasing the risk of age-related diseases such as diabetes or osteoporosis, thereby reducing overall healthspan
Maintaining the integrity of cellular communication systems, such as TRP channels, is crucial for sustaining health during ageing. This underlines the need for cautious use of medications like aminoglycosides that may disrupt these pathways, ensuring they do not compromise long-term health and vitality.
Read the article at: Fusi, Floriana, et al. “Aminoglycoside Antibiotics Inhibit TRP Channels: Consequences for Muscle and Adipose Tissue Development and Metabolic Balance.” Cells, vol. 13, no. 15, 2023, doi:10.3390/cells13151273.