Urolithin A, derived from gut metabolism, enhances mitochondrial function, reduces inflammation, and improves muscle strength and endurance. It offers potential benefits for healthy ageing but does not affect body composition or overall physical function. Further research is needed to explore its impact on various systems and its long-term benefits.
September 2024 – Science Direct
Key takeaways
- Urolithin A supports mitochondrial health: Mitochondria are often referred to as the powerhouses of cells, but their function diminishes as we age, leading to fatigue and cellular ageing. Urolithin A activates autophagy and mitophagy, processes that recycle damaged mitochondria and promote the generation of healthier ones. This supports cellular energy levels, improving resilience against age-related decline
- Anti-inflammatory effects are dose-dependent: Chronic inflammation is a hallmark of ageing and a contributor to conditions like arthritis, cardiovascular diseases, and neurodegeneration. Urolithin A reduces inflammation by suppressing key inflammatory markers, especially when taken in higher doses. This targeted action may help slow down or prevent the progression of age-related illnesses tied to systemic inflammation
- Improves muscle strength and endurance: Ageing often brings sarcopenia, the loss of muscle mass and strength. Urolithin A supplementation has been shown to enhance the force and endurance of key muscle groups, potentially aiding older adults in maintaining mobility and independence. This effect is particularly valuable for those experiencing muscle decline due to inactivity or other factors
Although Urolithin A shows promising results in muscle and mitochondrial health, its effects on broader physical performance, such as cardiovascular endurance or gut microbiota diversity, remain minimal. This suggests that Urolithin A should complement, rather than replace, a comprehensive health and longevity strategy involving exercise, diet, and other interventions.
Read the article at: Kuerec, Ajla Hodzic, et al. “Targeting Aging with Urolithin A in Humans: A Systematic Review.” Ageing Research Reviews, vol. 100, 2024, p. 102406. Elsevier, doi:10.1016/j.arr.2024.102406.