SCIENTIFIC RESEARCH

Urolithin A boosts muscle strength and endurance in middle age

01.02.2025

Urolithin A supplementation enhances muscle strength, aerobic endurance, and mitochondrial efficiency in middle-aged adults. It activates mitophagy, improves walking distance, and reduces inflammation markers, supporting muscle function and longevity. The findings highlight its potential as a nutritional intervention for healthy ageing​.

May 2022 – Cell Reports Medicine

 

Key takeaways

 

  • Improves muscle strength and endurance: Urolithin A significantly enhances leg muscle strength, walking distance, and aerobic capacity. These improvements support mobility, reduce fatigue, and help maintain independence as people age. Enhancing exercise performance without requiring additional training, offers a promising strategy for combating age-related muscle decline and improving overall physical resilience
  • Enhances mitochondrial function: It stimulates mitophagy, the body’s process of clearing out damaged mitochondria, which enhances energy production and cellular efficiency. This mechanism is crucial for slowing age-related decline, as mitochondrial dysfunction is linked to muscle loss, reduced endurance, and chronic fatigue. Better mitochondrial health supports sustained energy levels, metabolic function, and overall longevity
  • Reduces systemic inflammation: Urolithin A supplementation lowers key inflammatory markers like C-reactive protein, which is associated with ageing-related diseases such as cardiovascular conditions and metabolic disorders. By reducing inflammation at a cellular level, it may help protect against chronic illness, improve recovery, and promote healthier ageing by maintaining optimal immune and metabolic function over time
  • Safe for long-term use: Regular supplementation is well tolerated, with no significant adverse effects reported. Unlike pharmaceutical interventions, it provides a natural and sustainable way to enhance muscle health and longevity. Its ability to improve physical function without requiring lifestyle changes makes it an accessible option for those seeking to preserve vitality and slow age-related decline

 

Read the article at: Singh, Anurag, et al. “Urolithin A Improves Muscle Strength, Exercise Performance, and Biomarkers of Mitochondrial Health in a Randomized Trial in Middle-Aged Adults.” Cell Reports Medicine, vol. 3, no. 5, 2022, https://doi.org/10.1016/j.xcrm.2022.100633.

 

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