Regular consumption of sugar-sweetened drinks was linked to over 3 million new diabetes and heart disease cases globally in 2020, with the highest burdens in Latin America and sub-Saharan Africa. Younger, urban, and more educated adults were most affected, highlighting urgent need for targeted prevention and policy action.
SGLT2 inhibitors show promise for longevity and disease prevention
SGLT2 inhibitors, originally for type 2 diabetes, show broad potential to slow ageing, prevent age-related diseases, and extend healthspan and lifespan. They enhance autophagy, reduce oxidative stress, rejuvenate mitochondria, and protect against heart, kidney, brain, and metabolic decline, even in non-diabetics, with a strong safety profile.
Brown fat’s role in healthy ageing and performance
Brown adipose tissue enhances exercise capacity and supports healthful ageing by improving metabolism, vascular function, and resistance to age-related diseases. Transplanting BAT, especially from long-lived RGS14 knockout mice, boosts performance and longevity, highlighting its potential as a therapeutic target for promoting vitality and extended healthspan.
Why foundational health habits trump any biohacking tech
From wearable trackers to cryotherapy chambers, these innovations promise optimisation and peak performance. But amidst all the hype, one truth remains unchanged: no gadget can replace the power of foundational health habits.
How essential oils at night boosted memory in older adults
Nightly exposure to essential oils significantly enhanced memory and altered brain structure in older adults. A simple 2-hour olfactory enrichment using diffusers improved verbal recall and modified key neural pathways, offering a low-effort, non-invasive approach to support cognitive health and brain ageing.
Gene therapy extends lifespan without cancer risk
Genetic activation of telomerase in mice significantly extended lifespan and improved healing of skin and intestinal injuries, without increasing cancer risk. This targeted intervention boosted cellular repair, antioxidant defences, and telomere length, offering a promising strategy for enhancing longevity and resilience to age-related decline.
The surprising split in ageing research beliefs
Despite major progress in ageing science, researchers hold vastly different views on its causes, definitions, onset, and reversibility. This diversity reveals a critical need for clearer shared understanding, as current disagreements may hinder the development of effective strategies to extend healthspan and tackle biological ageing more precisely.
Ketones help the ageing brain clear toxic proteins
Ketone body β-hydroxybutyrate helps clear misfolded, toxic proteins from the ageing and Alzheimer’s brain. By selectively targeting unstable proteins for removal, it supports cellular detox and brain resilience. This natural fasting-related molecule could be key to enhancing proteostasis, cognitive function, and long-term neurological health.
How mitochondrial changes in muscle signal early ageing
Ageing impairs skeletal muscle function, linked to reduced subsarcolemmal mitochondrial density, fragmented intermyofibrillar networks, and lower cristae density. These mitochondrial changes strongly associate with diminished physical capacity, highlighting mitochondria’s role in age-related muscle decline.
Pro-ageing metabolic reprogramming and its impact on healthspan
Ageing is driven by metabolic shifts that disrupt cellular function over time. This research explores how pro-ageing metabolic reprogramming accelerates decline, linking it to key hallmarks of ageing. Understanding these processes could unlock new strategies to delay ageing and enhance healthspan through targeted metabolic interventions.
