An Astragalus-based supplement taken daily for six months significantly increased telomere length in healthy middle-aged adults, suggesting measurable anti-ageing and longevity benefits without adverse effects.
Living higher, ageing slower: the altitude effect
Higher altitude living in Ethiopia is linked to lower disease burden, reduced DNA damage-related senescence, and longer life expectancy, despite signs of increased facial ageing from UV exposure.
The unseen toll of sugar-sweetened beverages worldwide
Regular consumption of sugar-sweetened drinks was linked to over 3 million new diabetes and heart disease cases globally in 2020, with the highest burdens in Latin America and sub-Saharan Africa. Younger, urban, and more educated adults were most affected, highlighting urgent need for targeted prevention and policy action.
SGLT2 inhibitors show promise for longevity and disease prevention
SGLT2 inhibitors, originally for type 2 diabetes, show broad potential to slow ageing, prevent age-related diseases, and extend healthspan and lifespan. They enhance autophagy, reduce oxidative stress, rejuvenate mitochondria, and protect against heart, kidney, brain, and metabolic decline, even in non-diabetics, with a strong safety profile.
Brown fat’s role in healthy ageing and performance
Brown adipose tissue enhances exercise capacity and supports healthful ageing by improving metabolism, vascular function, and resistance to age-related diseases. Transplanting BAT, especially from long-lived RGS14 knockout mice, boosts performance and longevity, highlighting its potential as a therapeutic target for promoting vitality and extended healthspan.
Why foundational health habits trump any biohacking tech
From wearable trackers to cryotherapy chambers, these innovations promise optimisation and peak performance. But amidst all the hype, one truth remains unchanged: no gadget can replace the power of foundational health habits.
Ketones help the ageing brain clear toxic proteins
Ketone body β-hydroxybutyrate helps clear misfolded, toxic proteins from the ageing and Alzheimer’s brain. By selectively targeting unstable proteins for removal, it supports cellular detox and brain resilience. This natural fasting-related molecule could be key to enhancing proteostasis, cognitive function, and long-term neurological health.
How mitochondrial changes in muscle signal early ageing
Ageing impairs skeletal muscle function, linked to reduced subsarcolemmal mitochondrial density, fragmented intermyofibrillar networks, and lower cristae density. These mitochondrial changes strongly associate with diminished physical capacity, highlighting mitochondria’s role in age-related muscle decline.
Red light therapy boosts mitochondrial function and reduces blood glucose
Exposure to 670 nm red light for 15 minutes significantly reduces blood glucose levels in healthy individuals, as shown by a glucose tolerance test. This photobiomodulation enhances mitochondrial function, potentially aiding metabolic health and reducing glucose spikes, which may support wellness, healthspan, and longevity by mitigating age-related metabolic decline.
Creatine enhances cognitive performance and brain energy under stress
A single high dose of creatine improved cognitive performance and brain energy metabolism during sleep deprivation, reversing fatigue-related declines. It enhanced processing speed, memory, and prevented metabolic changes, suggesting creatine may support brain function under stress, potentially benefiting wellness and healthspan during ageing.
