Ageing disrupts vesicle transport in brain endothelial cells, impairing cellular recycling and barrier integrity. This dysfunction, linked to decreased Arf6 protein and increased Apoe cargo, accelerates vascular ageing and may contribute to neurodegenerative decline, highlighting a crucial mechanism in brain health and longevity.
Rapamycin restores tendon-to-bone healing in ageing joints
Rapamycin significantly improves tendon-to-bone healing in ageing by enhancing bone growth, fibrocartilage regeneration, and tendon repair, leading to better structural and functional recovery after injury.
MIND diet may protect against dementia and death
Greater long-term adherence to the MIND diet is linked with slower biological ageing and a lower risk of dementia and death, with part of this protection mediated through reduced systemic ageing, as measured by a DNA methylation biomarker.
What aged organ transplants reveal about accelerated ageing
Transplanting older organs into younger recipients accelerates physical and cognitive decline by spreading cellular senescence, driven by factors like mitochondrial DNA. Treating donor organs with senolytics before transplantation reduces this impact, offering a promising strategy to improve health outcomes.
Reducing isoleucine boosts metabolic health and longevity
Limiting dietary isoleucine, an amino acid, boosts metabolic health, reduces frailty, and extends lifespan in genetically diverse mice, especially males. Starting this restriction in mid-life enhances healthspan without calorie reduction, suggesting that protein quality, specifically amino acid composition, may be crucial for promoting healthy ageing and increasing longevity.
Vision loss could signal dementia risk in older adults
Older adults in the US with objectively measured visual impairments, especially multiple types, were significantly more likely to experience dementia, highlighting vision health as a potential lever for preserving cognitive function.
Oral microbiome testing: What’s really living in your mouth
The oral microbiome plays a powerful role in inflammation, immunity, brain health, and longevity – often silently. With advanced testing now available, you can uncover imbalances and target hidden drivers of systemic issues, performance limits, or disease risk.
Restoring senescent cells with sound waves
Low-frequency ultrasound restores the function and growth of senescent cells by reversing ageing markers, enhancing cellular vitality, and extending healthspan and lifespan in mice, offering a non-invasive route to rejuvenation.
Torpor-like states reduce biological age in mice
Inducing a torpor-like state in mice significantly slowed blood epigenetic ageing and improved healthspan, revealing that a sustained drop in core body temperature, not calorie restriction or metabolic rate, is key to decelerating molecular ageing and promoting vitality.
Men’s Health Week: Taking control of your health from 30 to 100
Celebrate Men’s Health Week by taking charge of your health at every age. From your 30s to your 90s, discover proactive, data-driven strategies to extend your healthspan, prevent disease, and optimise wellbeing through each decade of life.
