Regular consumption of sugar-sweetened drinks was linked to over 3 million new diabetes and heart disease cases globally in 2020, with the highest burdens in Latin America and sub-Saharan Africa. Younger, urban, and more educated adults were most affected, highlighting urgent need for targeted prevention and policy action.
SGLT2 inhibitors show promise for longevity and disease prevention
SGLT2 inhibitors, originally for type 2 diabetes, show broad potential to slow ageing, prevent age-related diseases, and extend healthspan and lifespan. They enhance autophagy, reduce oxidative stress, rejuvenate mitochondria, and protect against heart, kidney, brain, and metabolic decline, even in non-diabetics, with a strong safety profile.
The surprising split in ageing research beliefs
Despite major progress in ageing science, researchers hold vastly different views on its causes, definitions, onset, and reversibility. This diversity reveals a critical need for clearer shared understanding, as current disagreements may hinder the development of effective strategies to extend healthspan and tackle biological ageing more precisely.
Cracking the pain code: What your symptoms are really telling you
Pain is more than just tissue damage, it’s a protective mechanism shaped by biomechanics, biochemistry, and context. Guest author, Dr Bella Lord (MOSIC), explores how pain works, why perception varies, and how addressing lifestyle factors can help manage and resolve persistent pain.
PhotoAgeClock: Deep learning predicts ageing through eye corner analysis
A deep-learning model has been developed to estimate chronological age using high-resolution images of eye corners. This non-invasive approach outperforms DNA methylation clocks in accuracy and could help assess lifestyle, medical, and cosmetic interventions for ageing. Wrinkles and skin pigmentation serve as key visual biomarkers.
The role of mitochondria in youthful skin and longevity
Mitochondria are central to skin health, influencing ageing and disease. Their dysfunction leads to oxidative stress, accelerating wrinkles, pigmentation changes, and skin disorders. Targeting mitochondria through antioxidants and energy-boosting compounds offers potential for skin rejuvenation, making mitochondrial health a key focus for longevity and wellness.
How senescent cells help regenerate damaged cartilage
Cellular senescence aids meniscus repair. Once thought to drive ageing, senescent cells release signals that promote healing. In rats, these cells help regenerate damaged knee cartilage. Removing them impairs recovery, suggesting that harnessing their regenerative effects could offer new strategies for joint repair and longevity.
Ferroptosis and cellular senescence in ageing and wellness
Ferroptosis, a regulated form of cell death driven by iron-dependent lipid peroxidation, is intricately linked to aging and cellular senescence. Understanding and modulating ferroptosis may offer novel ways to address age-related diseases, improve healthspan, and promote longevity by reducing tissue dysfunction and enhancing overall well-being.
Ageing’s key transition periods and their impact on health
Ageing undergoes two key periods of rapid change: early adulthood and later life. These transitions significantly impact health and biological ageing, offering opportunities to target interventions and optimise healthspan during these critical phases.
The impact of TRP channel inhibition on longevity
Aminoglycoside antibiotics, such as streptomycin, can inhibit TRP channels, disrupting calcium signalling essential for muscle and adipose tissue development. This interference may impair metabolic balance, potentially affecting healthspan and longevity.
