Blocking IL-11, a pro-inflammatory protein, extended lifespan and improved health in mice, reducing frailty and metabolic decline. Inhibiting IL-11 led to a lifespan increase of up to 25%, showing promise as a therapeutic target for enhancing human healthspan.
The impact of hydrogen peroxide on cellular stress and longevity
Mitochondrial hydrogen peroxide (H2O2) doesn’t directly harm chromosomal DNA but plays a role in redox signalling, which helps regulate cellular responses to oxidative stress. This suggests that H2O2 has a more complex function in ageing, highlighting potential therapeutic strategies to reduce oxidative damage while maintaining its beneficial signalling effects.
Medicine 3.0 and functional medicine: How they overlap in Australia
Medicine 3.0 and functional medicine share a focus on personalised, preventative care aimed at optimising long-term health. At Melbourne Functional Medicine, this approach means addressing root causes, promoting longevity, and empowering patients to take charge of their wellbeing.
Stem cell-derived islet tissues offer insulin independence
Autologous stem cell-derived islet tissues restored insulin function in a type 2 diabetes patient, achieving glycemic control, insulin independence, and no tumor formation over 116 weeks.
TERT activation and its potential to reverse ageing markers
A TERT activator was found to promote telomere synthesis, reduce cellular senescence, and alleviate neuroinflammation in aged mice, improving cognitive function. It achieved this by upregulating TERT transcription through the MEK/ERK/AP-1 pathway, reducing key ageing markers like p16 through DNA methylation, without increasing cancer risk.
Cellular senescence and its impact on metabolic ageing
Cellular senescence, where cells stop dividing but remain metabolically active, leads to the release of harmful molecules that drive ageing and metabolic dysfunction. Addressing the metabolic changes in senescent cells could help reduce ageing effects and related diseases.
POT1 and CST-Polα/primase protect telomeres and support healthy ageing
POT1 recruits and regulates the CST-Polα/primase complex at human telomeres, ensuring proper telomere replication and maintenance. This process is vital for maintaining genome stability, which plays a key role in aging, longevity, and preventing age-related diseases linked to telomere dysfunction.
MYCT1 gene discovery reveals key to blood stem cell renewal and longevity
MYCT1 is essential for how human hematopoietic stem cells (HSCs) sense and respond to their environment, which is crucial for their self-renewal and long-term function. This discovery points to potential therapies that could maintain healthy blood stem cells, support immune function, and enhance longevity by preserving stem cell regenerative abilities.
Life’s essential 8 slows biological ageing and reduces cardiovascular risk
Adhering to “Life’s Essential 8” is associated with reduced cardiovascular disease and mortality, primarily through a younger epigenetic age, underscoring the importance of lifestyle in slowing biological ageing and promoting longevity.
TruAge: How discovering your ‘real age’ can help you age better
TruAge measures biological age using advanced technology to assess gene methylation, telomere length, and stem cell divisions. Learn how the results of this test can guide personalised strategies to slow ageing and optimise health.
