When lysosomal function is impaired, cells release dysfunctional mitochondria through large extracellular vesicles instead of breaking them down. This process occurs independently of autophagy, helps preserve cellular health, and is observed in aged or diseased heart tissues, offering insights into ageing and cardiac disease.
The top 20 female health leaders of 2024
Longevity, biohacking and science in general can often feel like a domain dominated by male voices. But when you scratch beneath the surface, there are some incredible female voices in the space. Health coach Liv shares her top 20 for 2024.
Human cells create self-healing biobots for regenerative medicine and ageing
Anthrobots are motile biobots made from adult human lung cells, showcasing the plasticity of human tissues. These spheroid-shaped biobots, driven by cilia, demonstrate varied movement patterns and can repair damaged tissues, presenting new possibilities in regenerative medicine and bioengineering.
Life’s essential 8 slows biological ageing and reduces cardiovascular risk
Adhering to “Life’s Essential 8” is associated with reduced cardiovascular disease and mortality, primarily through a younger epigenetic age, underscoring the importance of lifestyle in slowing biological ageing and promoting longevity.
Cardiorespiratory fitness: A key predictor of lifespan and healthspan
Higher cardiorespiratory fitness (CRF) significantly reduces the risk of chronic diseases and death. Involving 20.9 million participants from 199 studies, this analysis highlights CRF’s crucial role in enhancing healthspan and longevity.
TruAge: How discovering your ‘real age’ can help you age better
TruAge measures biological age using advanced technology to assess gene methylation, telomere length, and stem cell divisions. Learn how the results of this test can guide personalised strategies to slow ageing and optimise health.
Rejuvenating aged stem cells to extend health and lifespan
Key strategies to rejuvenate aged stem cells and extend healthspan and lifespan include physical exercise, diet manipulation, targeting senescence, autophagy, epigenetic reprogramming, and using circulating blood factors. These methods enhance tissue homeostasis and regenerative capacity, potentially improving overall health and longevity.
Reversing muscle ageing with heavy resistance training
Human skeletal muscle ageing features irregular myofiber shapes, especially in type II fibres, leading to reduced muscle function and mass. Heavy resistance training can reverse these changes, improving muscle health in the elderly.
Efficient DNA-protein crosslink repair enhances longevity
Endogenous aldehyde-induced DNA-protein crosslinks (DPCs) are efficiently resolved by transcription-coupled repair (TCR), protecting against metabolic genotoxins. This process explains the molecular pathogenesis of diseases like AMeDS and Cockayne syndrome. Effective aldehyde clearance and TCR are crucial for maintaining genomic integrity in transcribed regions.
Mitochondrial H2O2 and its indirect role in ageing
Mitochondrial H2O2 release doesn’t directly damage chromosomal DNA but influences ageing through signalling pathways, offering potential targets for anti-ageing interventions.
