A single high dose of creatine improved cognitive performance and brain energy metabolism during sleep deprivation, reversing fatigue-related declines. It enhanced processing speed, memory, and prevented metabolic changes, suggesting creatine may support brain function under stress, potentially benefiting wellness and healthspan during ageing.
Dietary vitamin K supports brain health in ageing adults
Higher dietary vitamin K intake is linked to lower levels of neurofilament light chain, a marker of neurodegeneration, particularly in middle-aged and older adults. This suggests vitamin K may support brain health and potentially slow age-related cognitive decline, offering a nutritional strategy for promoting longevity and healthy ageing.
AI predicts ageing through hand and facial biomarkers
AI analysis of dorsal hand and facial images predicts chronological age in Indian females with high accuracy, identifying key ageing markers. Hand images, showing knuckle texture as a significant feature, offer a viable alternative to facial images for age prediction, supporting applications in healthspan and longevity research.
Biohacking sleep: 10 steps to improve sleep quality for optimal health
Sleep isn’t just downtime – it’s a structured physiological process crucial for cellular repair, immune function, memory consolidation, and longevity. Optimising sleep involves improving your daily habits, environment, and using targeted technologies and supplements. Understanding your personal sleep data allows tailored strategies for enhanced health and performance.
PhotoAgeClock: Deep learning predicts ageing through eye corner analysis
A deep-learning model has been developed to estimate chronological age using high-resolution images of eye corners. This non-invasive approach outperforms DNA methylation clocks in accuracy and could help assess lifestyle, medical, and cosmetic interventions for ageing. Wrinkles and skin pigmentation serve as key visual biomarkers.
The role of mitochondria in youthful skin and longevity
Mitochondria are central to skin health, influencing ageing and disease. Their dysfunction leads to oxidative stress, accelerating wrinkles, pigmentation changes, and skin disorders. Targeting mitochondria through antioxidants and energy-boosting compounds offers potential for skin rejuvenation, making mitochondrial health a key focus for longevity and wellness.
High-intensity exercise reduces muscle ageing through inflammation
High-intensity interval exercise (HIIE) reduces cellular senescence in human muscles through acute inflammation, as shown by decreased p16INK4a and CD11b mRNA levels. Blocking inflammation with ibuprofen attenuates these effects, highlighting the role of inflammation in exercise-induced muscle rejuvenation and its potential for enhancing healthspan and longevity.
How senescent cells help regenerate damaged cartilage
Cellular senescence aids meniscus repair. Once thought to drive ageing, senescent cells release signals that promote healing. In rats, these cells help regenerate damaged knee cartilage. Removing them impairs recovery, suggesting that harnessing their regenerative effects could offer new strategies for joint repair and longevity.
Ferroptosis and cellular senescence in ageing and wellness
Ferroptosis, a regulated form of cell death driven by iron-dependent lipid peroxidation, is intricately linked to aging and cellular senescence. Understanding and modulating ferroptosis may offer novel ways to address age-related diseases, improve healthspan, and promote longevity by reducing tissue dysfunction and enhancing overall well-being.
Benzyl butyl phthalate (BBP) exposure damages DNA and accelerates ageing
Benzyl butyl phthalate (BBP), a common plasticiser, disrupts reproductive health by increasing DNA damage and oxidative stress. Exposure impairs chromosome stability and gene expression, potentially affecting fertility and ageing. Findings highlight concerns about environmental toxins’ impact on longevity and underscore the need for minimising exposure.
