A single high dose of creatine improved cognitive performance and brain energy metabolism during sleep deprivation, reversing fatigue-related declines. It enhanced processing speed, memory, and prevented metabolic changes, suggesting creatine may support brain function under stress, potentially benefiting wellness and healthspan during ageing.
AI predicts ageing through hand and facial biomarkers
AI analysis of dorsal hand and facial images predicts chronological age in Indian females with high accuracy, identifying key ageing markers. Hand images, showing knuckle texture as a significant feature, offer a viable alternative to facial images for age prediction, supporting applications in healthspan and longevity research.
Biohacking sleep: 10 steps to improve sleep quality for optimal health
Sleep isn’t just downtime – it’s a structured physiological process crucial for cellular repair, immune function, memory consolidation, and longevity. Optimising sleep involves improving your daily habits, environment, and using targeted technologies and supplements. Understanding your personal sleep data allows tailored strategies for enhanced health and performance.
PhotoAgeClock: Deep learning predicts ageing through eye corner analysis
A deep-learning model has been developed to estimate chronological age using high-resolution images of eye corners. This non-invasive approach outperforms DNA methylation clocks in accuracy and could help assess lifestyle, medical, and cosmetic interventions for ageing. Wrinkles and skin pigmentation serve as key visual biomarkers.
The role of mitochondria in youthful skin and longevity
Mitochondria are central to skin health, influencing ageing and disease. Their dysfunction leads to oxidative stress, accelerating wrinkles, pigmentation changes, and skin disorders. Targeting mitochondria through antioxidants and energy-boosting compounds offers potential for skin rejuvenation, making mitochondrial health a key focus for longevity and wellness.
Ferroptosis and cellular senescence in ageing and wellness
Ferroptosis, a regulated form of cell death driven by iron-dependent lipid peroxidation, is intricately linked to aging and cellular senescence. Understanding and modulating ferroptosis may offer novel ways to address age-related diseases, improve healthspan, and promote longevity by reducing tissue dysfunction and enhancing overall well-being.
Machine learning designs gene regulators to slow ageing
Machine learning is used to design synthetic gene regulators that precisely target specific cell types, outperforming natural sequences. This could enable highly targeted therapies for ageing-related diseases, improving gene therapy precision and reducing off-target effects, potentially enhancing longevity by addressing cellular dysfunction more effectively.
Urolithin A boosts muscle strength and endurance in middle age
Urolithin A supplementation enhances muscle strength, aerobic endurance, and mitochondrial efficiency in middle-aged adults. It activates mitophagy, improves walking distance, and reduces inflammation markers, supporting muscle function and longevity. The findings highlight its potential as a nutritional intervention for healthy ageing
DVE-1 and longevity regulation beyond mitochondrial stress
DVE-1 supports longevity in C. elegans through multiple pathways beyond its known role in mitochondrial stress response. It regulates lifespan independently of the mitochondrial unfolded protein response, influencing dietary restriction, germline signalling, and sensory perception. Its reduced nuclear presence in long-lived mutants suggests a broader cytosolic function in ageing.
Supercharge training outcomes with precise, adaptable and barefoot training
Discover how barefoot training, precision movement, and recovery can revolutionise your fitness. Learn key principles like aligning with natural biomechanics, prioritising technique, and embracing adaptability. Whether you’re an athlete or beginner, these insights will help you build strength, prevent injury, and achieve your goals effectively.
