A single transcription factor, NeuroD1, enables the direct conversion of brain-resident immune cells into functional neurons after stroke, restoring lost neurological function. This breakthrough shows promise for regenerating brain tissue, offering a potential future therapy for age-related neurodegeneration and stroke-induced disabilities by replenishing neurons within damaged areas.
Vision loss could signal dementia risk in older adults
Older adults in the US with objectively measured visual impairments, especially multiple types, were significantly more likely to experience dementia, highlighting vision health as a potential lever for preserving cognitive function.
Oral microbiome testing: What’s really living in your mouth
The oral microbiome plays a powerful role in inflammation, immunity, brain health, and longevity – often silently. With advanced testing now available, you can uncover imbalances and target hidden drivers of systemic issues, performance limits, or disease risk.
Hormesis: Using controlled stress to go harder, faster, stronger, smarter
Discover how small, controlled stressors like fasting, heat, cold, and low-oxygen training can trigger powerful adaptations in the body. Hormesis helps boost resilience, improve performance, sharpen cognition, and support healthy ageing – when done in the right dose.
Restoring the brain’s sugar shield boosts memory
Ageing disrupts a key sugar-protein layer called the glycocalyx lining brain blood vessels, weakening the blood–brain barrier and increasing brain inflammation and cognitive decline; restoring this layer in mice improves brain health and memory.
How essential oils at night boosted memory in older adults
Nightly exposure to essential oils significantly enhanced memory and altered brain structure in older adults. A simple 2-hour olfactory enrichment using diffusers improved verbal recall and modified key neural pathways, offering a low-effort, non-invasive approach to support cognitive health and brain ageing.
Ketones help the ageing brain clear toxic proteins
Ketone body β-hydroxybutyrate helps clear misfolded, toxic proteins from the ageing and Alzheimer’s brain. By selectively targeting unstable proteins for removal, it supports cellular detox and brain resilience. This natural fasting-related molecule could be key to enhancing proteostasis, cognitive function, and long-term neurological health.
Creatine enhances cognitive performance and brain energy under stress
A single high dose of creatine improved cognitive performance and brain energy metabolism during sleep deprivation, reversing fatigue-related declines. It enhanced processing speed, memory, and prevented metabolic changes, suggesting creatine may support brain function under stress, potentially benefiting wellness and healthspan during ageing.
Dietary vitamin K supports brain health in ageing adults
Higher dietary vitamin K intake is linked to lower levels of neurofilament light chain, a marker of neurodegeneration, particularly in middle-aged and older adults. This suggests vitamin K may support brain health and potentially slow age-related cognitive decline, offering a nutritional strategy for promoting longevity and healthy ageing.
Mitochondrial DNA insertions in the brain linked to ageing
Mitochondrial DNA fragments integrate into the nuclear genome (Numts), particularly in brain tissue, increasing with age and correlating with earlier mortality. In cultured fibroblasts, new insertions appear every 13 days, accelerating under stress and mitochondrial dysfunction, suggesting potential implications for ageing and longevity.
