Memory persistence relies on the interaction between KIBRA and PKMζ, maintaining synaptic strength despite molecular turnover. This partnership supports long-term memory by anchoring PKMζ to active synapses, essential for late-phase potentiation. Disrupting this interaction erases established memories, highlighting its role in sustaining memory longevity.
Microplastics found in the brain and their impact on ageing
Researchers detected microplastics in human brain tissue using pyrolysis gas chromatography-mass spectrometry, indicating potential bioaccumulation. This finding raises concerns about microplastics’ impact on neurological health and ageing.
Preserving cognitive function through improved lymphatic drainage
Restoring cervical lymphatic vessel function in ageing improves brain drainage, reduces inflammation, and enhances cognitive function. This approach could counter age-related cognitive decline, supporting healthier ageing and potentially extending healthspan.
Slowing brain ageing through region-specific Alzheimer’s insights
Single-cell analysis maps Alzheimer’s progression across brain regions, revealing specific cellular and molecular changes. The findings suggest targeted interventions could address Alzheimer’s-related dysfunction, potentially slowing progression and preserving brain health.
Reversing age-related brain decline with OSKM gene therapy
OSKM gene therapy in the hippocampus rejuvenates cognitive function in aged rats, improving spatial memory and cognitive abilities without harmful effects. The treatment reverses age-related DNA methylation changes, suggesting potential for brain rejuvenation and delaying cognitive decline.
The power of breathwork for health and performance
Imagine having a powerful wellness tool with you every single day—one that’s as simple as breathing. Turns out, your breath holds far more potential than most people realise.
TERT activation and its potential to reverse ageing markers
A TERT activator was found to promote telomere synthesis, reduce cellular senescence, and alleviate neuroinflammation in aged mice, improving cognitive function. It achieved this by upregulating TERT transcription through the MEK/ERK/AP-1 pathway, reducing key ageing markers like p16 through DNA methylation, without increasing cancer risk.
The impact of genetics and lifestyle on brain ageing and longevity
Genetic and modifiable risk factors affect brain regions vulnerable to aging and diseases like Alzheimer’s and schizophrenia. Key factors include diabetes, traffic-related air pollution, and alcohol intake. Modifying these risk factors could help protect these fragile brain regions, promoting healthier ageing.
Glymphatic system dysfunction and its impact on Alzheimer’s disease progression
Glymphatic system dysfunction in Alzheimer’s disease predicts amyloid deposition, neurodegeneration, and clinical progression. The ALPS index, measuring glymphatic activity, is lower in AD patients and is linked to faster amyloid accumulation, brain atrophy, and cognitive decline.
Microplastics impact behaviour and inflammation in young and old mice
Short-term exposure to polystyrene microplastics in drinking water caused behavioural changes and increased inflammation in both young and old mice, with age-specific variations in effects. This highlights potential health risks from microplastic pollution across different age groups.
