Mitochondrial hydrogen peroxide (H2O2) doesn’t directly harm chromosomal DNA but plays a role in redox signalling, which helps regulate cellular responses to oxidative stress. This suggests that H2O2 has a more complex function in ageing, highlighting potential therapeutic strategies to reduce oxidative damage while maintaining its beneficial signalling effects.
Medicine 3.0 and functional medicine: How they overlap in Australia
Medicine 3.0 and functional medicine share a focus on personalised, preventative care aimed at optimising long-term health. At Melbourne Functional Medicine, this approach means addressing root causes, promoting longevity, and empowering patients to take charge of their wellbeing.
Stem cell-derived islet tissues offer insulin independence
Autologous stem cell-derived islet tissues restored insulin function in a type 2 diabetes patient, achieving glycemic control, insulin independence, and no tumor formation over 116 weeks.
Senolytic therapies and their effect on bone health in postmenopausal women
Intermittent senolytic therapy with dasatinib and quercetin showed no significant decrease in bone resorption in postmenopausal women overall.
Fasting as a strategy for boosting cellular health and longevity
Regular fasting activates autophagy, reduces oxidative stress and inflammation, delays ageing-related diseases, enhances cellular repair, and promotes longevity by improving metabolic health, making it a promising strategy for healthy ageing and increased healthspan.
TERT activation and its potential to reverse ageing markers
A TERT activator was found to promote telomere synthesis, reduce cellular senescence, and alleviate neuroinflammation in aged mice, improving cognitive function. It achieved this by upregulating TERT transcription through the MEK/ERK/AP-1 pathway, reducing key ageing markers like p16 through DNA methylation, without increasing cancer risk.
Targeting Tregs to extend healthspan and delay the effects of ageing
Regulatory T cells (Tregs) help prevent stem cell exhaustion, a key factor in ageing. As Treg function declines with age, immune imbalance occurs, accelerating the ageing process. This contributes to various age-related diseases. Therapeutically targeting Tregs could slow immuno-ageing, promoting longevity and better health outcomes.
The link between blood biomarkers and longevity potential
Lower cholesterol and iron levels, alongside higher glucose, uric acid, and liver enzymes, are associated with a reduced chance of living to 100. These findings suggest a link between specific blood biomarkers and exceptional longevity, offering potential insights into the biological factors behind longer life expectancy.
Cellular senescence and its impact on metabolic ageing
Cellular senescence, where cells stop dividing but remain metabolically active, leads to the release of harmful molecules that drive ageing and metabolic dysfunction. Addressing the metabolic changes in senescent cells could help reduce ageing effects and related diseases.
Microplastics detected in human seminal fluid: Potential health risks
Microplastics were detected in human seminal fluid, raising concerns about their impact on male reproductive health and potential long-term effects on fertility and ageing. This study used Raman spectroscopy to highlight the prevalence of microplastic contamination in a sample of the general male population.
