Endogenous aldehyde-induced DNA-protein crosslinks (DPCs) are efficiently resolved by transcription-coupled repair (TCR), protecting against metabolic genotoxins. This process explains the molecular pathogenesis of diseases like AMeDS and Cockayne syndrome. Effective aldehyde clearance and TCR are crucial for maintaining genomic integrity in transcribed regions.
Mitochondrial H2O2 and its indirect role in ageing
Mitochondrial H2O2 release doesn’t directly damage chromosomal DNA but influences ageing through signalling pathways, offering potential targets for anti-ageing interventions.
Antioxidants combat age-related diseases by reducing oxidative stress
Antioxidants combat age-related diseases by reducing oxidative stress, potentially enhancing longevity and healthspan. Dietary intake and supplements are highlighted as effective strategies for promoting healthy ageing.
Bacterial muropeptides enhance mitochondrial health for healthy ageing
Bacterial muropeptides enhance mitochondrial functions and reduce oxidative stress in mammals. They promote oxidative phosphorylation (OXPHOS), improve mitochondrial structure, and support intestinal health. This suggests a potential therapeutic avenue for treating mitochondrial diseases by using muropeptides to stabilise and enhance ATP synthase activity.
Therapeutic strategies targeting miRNA and nutraceuticals for longevity
Nutraceuticals and miRNA-mediated pathways influence ageing, with therapeutic strategies targeting these pathways to enhance healthspan and longevity. Diet and molecular interventions hold potential for promoting healthier ageing.
The impact of genetics and lifestyle on brain ageing and longevity
Genetic and modifiable risk factors affect brain regions vulnerable to aging and diseases like Alzheimer’s and schizophrenia. Key factors include diabetes, traffic-related air pollution, and alcohol intake. Modifying these risk factors could help protect these fragile brain regions, promoting healthier ageing.
Glymphatic system dysfunction and its impact on Alzheimer’s disease progression
Glymphatic system dysfunction in Alzheimer’s disease predicts amyloid deposition, neurodegeneration, and clinical progression. The ALPS index, measuring glymphatic activity, is lower in AD patients and is linked to faster amyloid accumulation, brain atrophy, and cognitive decline.
Microplastics impact behaviour and inflammation in young and old mice
Short-term exposure to polystyrene microplastics in drinking water caused behavioural changes and increased inflammation in both young and old mice, with age-specific variations in effects. This highlights potential health risks from microplastic pollution across different age groups.
Glucose tracking with CGMs: Your longevity ally
CGMs have emerged as a powerful tool for monitoring and improving metabolic health and healthspan. Learn how you can transform this data into new habits to optimise your health.
Tardigrade proteins and their potential to enhance human longevity
Introducing tardigrade CAHS proteins into human cells induces reversible biostasis by forming gels that slow metabolism and protect cells during stress. This mechanism could enhance cell survival and longevity, potentially offering insights for advancing healthspan and ageing interventions.
