A newly identified brain-derived peptide, BRP, significantly reduces appetite and body weight in mice and pigs without causing nausea. This breakthrough uncovers a non-incretin pathway for appetite control, offering a promising, targeted approach for managing obesity and enhancing metabolic health.
Targeting NF-κB p65 to extend healthspan
Lowering of NF-κB p65 protein in the liver appears to be a common biological effect across a wide range of anti-ageing strategies, including dietary, pharmaceutical, and genetic interventions, highlighting this inflammatory regulator as a potential unifying target for promoting longevity and metabolic resilience.
Creatine benefits beyond the gym: Brain, bones, and better ageing
Creatine is fast becoming a must-have for health optimisers – fueling sharper thinking, stronger bones, balanced hormones, and better recovery. With standout benefits for women and ageing well, it’s a smart, science-backed upgrade for energy, resilience, and vitality.
Could Akkermansia muciniphila extend your healthspan
Genetic evidence links specific gut bacteria, especially Akkermansia muciniphila, to traits of healthy ageing. This microbe may enhance lifespan and physical function by influencing inflammation and metabolism, suggesting gut microbiota as a potential target for promoting longevity and delaying age-related decline.
The gut-longevity link: How your microbiome shapes your biological age
Your gut health plays a powerful role in how you age – affecting everything from immunity and energy to brain clarity and inflammation. Discover how microbiome testing and targeted gut support can enhance longevity, resilience, and overall wellbeing.
MIND diet may protect against dementia and death
Greater long-term adherence to the MIND diet is linked with slower biological ageing and a lower risk of dementia and death, with part of this protection mediated through reduced systemic ageing, as measured by a DNA methylation biomarker.
Reducing isoleucine boosts metabolic health and longevity
Limiting dietary isoleucine, an amino acid, boosts metabolic health, reduces frailty, and extends lifespan in genetically diverse mice, especially males. Starting this restriction in mid-life enhances healthspan without calorie reduction, suggesting that protein quality, specifically amino acid composition, may be crucial for promoting healthy ageing and increasing longevity.
Urolithin A reverses immune ageing by restoring stem cell health
Urolithin A supplementation revitalises ageing blood and immune systems by enhancing mitochondrial recycling in stem cells, restoring youthful blood cell production and boosting immune defence in older adults.
Oral microbiome testing: What’s really living in your mouth
The oral microbiome plays a powerful role in inflammation, immunity, brain health, and longevity – often silently. With advanced testing now available, you can uncover imbalances and target hidden drivers of systemic issues, performance limits, or disease risk.
Immune mastery: Optimise without overload for strong winter immunity
Stay resilient this winter by balancing stress and recovery. Learn to spot early signs of immune fatigue, adjust training and fasting to support immunity, and lean on sleep, nutrition, and connection to stay sharp and illness-free.
