Ageing disrupts vesicle transport in brain endothelial cells, impairing cellular recycling and barrier integrity. This dysfunction, linked to decreased Arf6 protein and increased Apoe cargo, accelerates vascular ageing and may contribute to neurodegenerative decline, highlighting a crucial mechanism in brain health and longevity.
Rapamycin restores tendon-to-bone healing in ageing joints
Rapamycin significantly improves tendon-to-bone healing in ageing by enhancing bone growth, fibrocartilage regeneration, and tendon repair, leading to better structural and functional recovery after injury.
What aged organ transplants reveal about accelerated ageing
Transplanting older organs into younger recipients accelerates physical and cognitive decline by spreading cellular senescence, driven by factors like mitochondrial DNA. Treating donor organs with senolytics before transplantation reduces this impact, offering a promising strategy to improve health outcomes.
Reducing isoleucine boosts metabolic health and longevity
Limiting dietary isoleucine, an amino acid, boosts metabolic health, reduces frailty, and extends lifespan in genetically diverse mice, especially males. Starting this restriction in mid-life enhances healthspan without calorie reduction, suggesting that protein quality, specifically amino acid composition, may be crucial for promoting healthy ageing and increasing longevity.
Reprogramming brain immune cells to restore function after stroke
A single transcription factor, NeuroD1, enables the direct conversion of brain-resident immune cells into functional neurons after stroke, restoring lost neurological function. This breakthrough shows promise for regenerating brain tissue, offering a potential future therapy for age-related neurodegeneration and stroke-induced disabilities by replenishing neurons within damaged areas.
Urolithin A reverses immune ageing by restoring stem cell health
Urolithin A supplementation revitalises ageing blood and immune systems by enhancing mitochondrial recycling in stem cells, restoring youthful blood cell production and boosting immune defence in older adults.
Oral microbiome testing: What’s really living in your mouth
The oral microbiome plays a powerful role in inflammation, immunity, brain health, and longevity – often silently. With advanced testing now available, you can uncover imbalances and target hidden drivers of systemic issues, performance limits, or disease risk.
Immune mastery: Optimise without overload for strong winter immunity
Stay resilient this winter by balancing stress and recovery. Learn to spot early signs of immune fatigue, adjust training and fasting to support immunity, and lean on sleep, nutrition, and connection to stay sharp and illness-free.
What steep survival curves mean for your healthspan
Some longevity interventions compress the time spent in poor health by steepening the survival curve. These steepening strategies – unlike those that merely extend lifespan – can reduce relative sickspan, offering a route to longer and healthier lives.
Slower biological ageing linked to daily multivitamins
Daily multivitamin use slowed biological ageing by 10–20% over two years in older adults, as measured by advanced epigenetic clocks, suggesting a promising strategy to support healthy ageing when combined with good nutrition and lifestyle habits
