Mitochondrial DNA fragments integrate into the nuclear genome (Numts), particularly in brain tissue, increasing with age and correlating with earlier mortality. In cultured fibroblasts, new insertions appear every 13 days, accelerating under stress and mitochondrial dysfunction, suggesting potential implications for ageing and longevity.
N6-Methyladenine in mitochondrial DNA and its role in ageing
Mitochondrial DNA progressively accumulates N6-methyladenine (6mA) with age, potentially serving as an ageing biomarker. In long-lived mutants, this methylation rate slows, linking mitochondrial epigenetics to longevity. The findings highlight mitochondrial DNA’s role in ageing and introduce a precise, cost-effective method for measuring 6mA levels.
The unique mechanism of DdrC in enhancing DNA stability
DdrC, a DNA repair protein from Deinococcus radiodurans, recognises and stabilises DNA breaks by binding to both single-stranded and double-stranded lesions. It bridges and compacts DNA through a novel mechanism dependent on structural asymmetry, enhancing repair efficiency and supporting the bacterium’s exceptional resistance to DNA damage.
Ageing’s key transition periods and their impact on health
Ageing undergoes two key periods of rapid change: early adulthood and later life. These transitions significantly impact health and biological ageing, offering opportunities to target interventions and optimise healthspan during these critical phases.
Powerful molecules for health and longevity: Our top 20
Discover 20 game-changing molecules that support optimal health and longevity. From enhancing energy and resilience to targeting the hallmarks of ageing, this guide dives into the science behind each molecule and its potential to help you live a longer, healthier life. Spoiler alert: Personalisation is key.
Healthspan vs lifespan: What’s the difference?
Discover the difference between living long and living well! Mark’s blog dives into healthspan vs lifespan, explains why biological age matters, and shares how small, impactful lifestyle changes can help you stay healthier for longer.
Slowing brain ageing through region-specific Alzheimer’s insights
Single-cell analysis maps Alzheimer’s progression across brain regions, revealing specific cellular and molecular changes. The findings suggest targeted interventions could address Alzheimer’s-related dysfunction, potentially slowing progression and preserving brain health.
Reversing age-related brain decline with OSKM gene therapy
OSKM gene therapy in the hippocampus rejuvenates cognitive function in aged rats, improving spatial memory and cognitive abilities without harmful effects. The treatment reverses age-related DNA methylation changes, suggesting potential for brain rejuvenation and delaying cognitive decline.
SIRT6’s role in slowing ageing and preventing diseases
SIRT6 regulates DNA repair and metabolic pathways, extending lifespan in mice by stabilising chromatin structure and preventing age-related diseases. This highlights potential therapeutic strategies for improving healthspan and longevity.
Tracking DNA methylation: A new biomarker for ageing
The PRC2-AgeIndex is a biomarker that tracks age-related changes in DNA methylation at specific sites linked to the Polycomb Repressive Complex 2 (PRC2). It effectively measures methylation gains in somatic cells and may help assess the impact of anti-aging treatments across different tissues
