Machine learning is used to design synthetic gene regulators that precisely target specific cell types, outperforming natural sequences. This could enable highly targeted therapies for ageing-related diseases, improving gene therapy precision and reducing off-target effects, potentially enhancing longevity by addressing cellular dysfunction more effectively.
Urolithin A boosts muscle strength and endurance in middle age
Urolithin A supplementation enhances muscle strength, aerobic endurance, and mitochondrial efficiency in middle-aged adults. It activates mitophagy, improves walking distance, and reduces inflammation markers, supporting muscle function and longevity. The findings highlight its potential as a nutritional intervention for healthy ageing
DVE-1 and longevity regulation beyond mitochondrial stress
DVE-1 supports longevity in C. elegans through multiple pathways beyond its known role in mitochondrial stress response. It regulates lifespan independently of the mitochondrial unfolded protein response, influencing dietary restriction, germline signalling, and sensory perception. Its reduced nuclear presence in long-lived mutants suggests a broader cytosolic function in ageing.
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The limits of human longevity in the twenty-first century
Radical human life extension is deemed unlikely this century. Since 1990, improvements in life expectancy have slowed, and reaching age 100 remains rare without breakthroughs in slowing biological ageing. Maximum lifespan is constrained by biological limits and diminishing returns on public health advancements
Genetic variability and the effects of dietary restriction on lifespan
Caloric restriction (20%-40%) and intermittent fasting enhanced lifespan in genetically diverse mice, with stronger effects tied to stricter calorie reduction. Lifespan varied with genetics and stress resilience, revealing healthspan and longevity are not always aligned. Extreme restrictions caused adverse effects, questioning optimal dietary strategies for ageing.
Urolithin A and its role in optimising ageing health
Urolithin A, derived from gut metabolism, enhances mitochondrial function, reduces inflammation, and improves muscle strength and endurance. It offers potential benefits for healthy ageing but does not affect body composition or overall physical function. Further research is needed to explore its impact on various systems and its long-term benefits.
Body roundness index as a tool for promoting healthy ageing
The Body Roundness Index (BRI) has a U-shaped relationship with all-cause mortality, with both very low and high BRI linked to higher death risk. BRI, which reflects visceral fat more accurately than BMI, may serve as a valuable, non-invasive tool for assessing health risks, aiding longevity-focused strategies.
Epigenetic resilience in axolotls unlocks longevity insights
Axolotls exhibit stable DNA methylation beyond early life, suggesting epigenetic resilience linked to negligible senescence. While methylation predicts age during early years, it ceases thereafter, and regeneration events rejuvenate tissues, shedding light on their remarkable longevity and regeneration abilities. This offers molecular insights into ageing stability and tissue renewal.
Rapamycin relies on spermidine to boost lifespan and healthspan
Endogenous spermidine is crucial for rapamycin’s benefits, enhancing autophagy and extending lifespan. Blocking spermidine synthesis hinders these effects, highlighting its role in cellular health. Combining rapamycin with spermidine may optimise longevity interventions while mitigating side effects.
