Higher dietary vitamin K intake is linked to lower levels of neurofilament light chain, a marker of neurodegeneration, particularly in middle-aged and older adults. This suggests vitamin K may support brain health and potentially slow age-related cognitive decline, offering a nutritional strategy for promoting longevity and healthy ageing.
Urolithin A boosts muscle strength and endurance in middle age
Urolithin A supplementation enhances muscle strength, aerobic endurance, and mitochondrial efficiency in middle-aged adults. It activates mitophagy, improves walking distance, and reduces inflammation markers, supporting muscle function and longevity. The findings highlight its potential as a nutritional intervention for healthy ageing
Genetic variability and the effects of dietary restriction on lifespan
Caloric restriction (20%-40%) and intermittent fasting enhanced lifespan in genetically diverse mice, with stronger effects tied to stricter calorie reduction. Lifespan varied with genetics and stress resilience, revealing healthspan and longevity are not always aligned. Extreme restrictions caused adverse effects, questioning optimal dietary strategies for ageing.
Urolithin A and its role in optimising ageing health
Urolithin A, derived from gut metabolism, enhances mitochondrial function, reduces inflammation, and improves muscle strength and endurance. It offers potential benefits for healthy ageing but does not affect body composition or overall physical function. Further research is needed to explore its impact on various systems and its long-term benefits.
Body roundness index as a tool for promoting healthy ageing
The Body Roundness Index (BRI) has a U-shaped relationship with all-cause mortality, with both very low and high BRI linked to higher death risk. BRI, which reflects visceral fat more accurately than BMI, may serve as a valuable, non-invasive tool for assessing health risks, aiding longevity-focused strategies.
Rapamycin relies on spermidine to boost lifespan and healthspan
Endogenous spermidine is crucial for rapamycin’s benefits, enhancing autophagy and extending lifespan. Blocking spermidine synthesis hinders these effects, highlighting its role in cellular health. Combining rapamycin with spermidine may optimise longevity interventions while mitigating side effects.
Dietary protein tweaks that enhance longevity and healthspan
Restricting dietary isoleucine boosts metabolic health, decreases frailty, and extends lifespan in genetically diverse mice. Male mice benefit most, showing a 33% lifespan increase. This amino acid adjustment offers a promising, calorie-independent way to enhance healthspan and longevity.
Powerful molecules for health and longevity: Our top 20
Discover 20 game-changing molecules that support optimal health and longevity. From enhancing energy and resilience to targeting the hallmarks of ageing, this guide dives into the science behind each molecule and its potential to help you live a longer, healthier life. Spoiler alert: Personalisation is key.
Navigating the festive season: 6 ways to protect your health gains
The festive season doesn’t have to derail your health goals. With mindful strategies like stress management, enjoying treats without guilt, staying active, and prioritising rest, you can maintain balance and vitality. Discover practical tips to navigate the holidays with ease and enjoy the moments that matter most.
Dietary acid reduction as a pathway to healthy ageing
Reducing dietary acid through increased intake of fruits and vegetables or sodium bicarbonate supplementation slows chronic kidney disease progression, lowers systolic blood pressure, and improves cardiovascular health.
