Gene-length-dependent transcription decline (GLTD) in ageing organisms results in longer genes showing decreased expression. This decline, linked to DNA damage and polymerase stalling, contributes to ageing and age-related diseases like Alzheimer’s. Targeting GLTD offers potential therapeutic avenues for enhancing healthspan and longevity.
Benefits of ergothioneine for longevity and healthy ageing in male mice
Ergothioneine, a dietary supplement, effectively increases lifespan and reduces age-related declines in physical and cognitive functions in male mice. Regular intake shows promise in promoting longevity and mitigating the effects of ageing.
Mitochondrial dysfunction influences brain ageing and disease
Mitochondrial dysfunction is highlighted as a pivotal element in brain ageing and associated diseases, playing a significant role in energy shortages, elevated oxidative stress, and neuronal harm, driving the advancement of neurodegenerative conditions.
Sleep enhances brain health and longevity
Neuronal activity boosts cerebrospinal fluid flow to remove brain waste during sleep, potentially affecting longevity and ageing.
Fighting memory loss with KIBRA
KIBRA improves brain connectivity and memory, providing defense against memory decline linked to tauopathy, prevalent in neurodegenerative conditions.
Gut inflammation associated with ageing and Alzheimer’s risk
Higher gut inflammation levels are linked with ageing and Alzheimer’s disease, with elevated inflammation markers found in older individuals and those with Alzheimer’s, suggesting intestinal inflammation may contribute to the disease’s progression.
Alzheimer’s risk in hormone therapy recipients
A small group of patients treated with contaminated cadaveric pituitary-derived growth hormone, containing amyloid-beta seeds, developed Alzheimer’s disease years later, highlighting a potential treatment-induced route of Alzheimer’s transmission and emphasizing the importance of careful evaluation in biological treatments related to ageing and longevity.
New hope in Alzheimer’s through metabolic rescue
Aberrant protein S-nitrosylation in Alzheimer’s disease inhibits the TCA cycle, causing synaptic loss due to compromised mitochondrial metabolism. Treatment with dimethyl succinate bypasses this block, partially restoring mitochondrial function and reversing synapse loss, suggesting potential therapeutic strategies for addressing synaptic loss through mitochondrial energy metabolism rescue.
Brain health’s link to lymphatic drainage
Using fluorescent tracers in mice, researchers discovered that the nasopharyngeal lymphatic plexus is crucial for draining cerebrospinal fluid (CSF) to deep cervical lymph nodes. Unlike its downstream counterparts, this plexus lacks smooth muscle but has unique valves and structure. With age, it atrophies, although CSF drainage can still be enhanced through specific signalling pathways, suggesting potential treatments for age-related neurological conditions by improving CSF clearance.
Neuroprotection through dietary restriction and OXR1
OXR1, enhanced by dietary restriction, is key in delaying brain ageing. It supports the retromer, crucial for managing protein and lipid movement, thereby offering neuroprotection and aiding longevity.
