A humanised mouse model now produces mature, class-switched, and hypermutated antibodies, offering insights into immune responses and advancing vaccine and antibody therapy research. This model may accelerate immunity understanding, supporting healthspan and longevity research.
Slowing brain ageing through region-specific Alzheimer’s insights
Single-cell analysis maps Alzheimer’s progression across brain regions, revealing specific cellular and molecular changes. The findings suggest targeted interventions could address Alzheimer’s-related dysfunction, potentially slowing progression and preserving brain health.
Uridine’s role in rejuvenating ageing blood stem cells and boosting healthspan
Uridine rejuvenates aged hematopoietic stem cells in mice, enhancing blood cell function and countering age-related stem cell decline—an essential factor for promoting healthspan and longevity.
Extending longevity with mitochondrial and omega-3 support
Mitochondrial-targeted supplements like MitoQ, urolithin A, omega-3 fatty acids, and GlyNAC can enhance muscle health and physical function in ageing, potentially extending healthspan and promoting longevity.
Reversing age-related brain decline with OSKM gene therapy
OSKM gene therapy in the hippocampus rejuvenates cognitive function in aged rats, improving spatial memory and cognitive abilities without harmful effects. The treatment reverses age-related DNA methylation changes, suggesting potential for brain rejuvenation and delaying cognitive decline.
The power of breathwork for health and performance
Imagine having a powerful wellness tool with you every single day—one that’s as simple as breathing. Turns out, your breath holds far more potential than most people realise.
SIRT6’s role in slowing ageing and preventing diseases
SIRT6 regulates DNA repair and metabolic pathways, extending lifespan in mice by stabilising chromatin structure and preventing age-related diseases. This highlights potential therapeutic strategies for improving healthspan and longevity.
Tracking DNA methylation: A new biomarker for ageing
The PRC2-AgeIndex is a biomarker that tracks age-related changes in DNA methylation at specific sites linked to the Polycomb Repressive Complex 2 (PRC2). It effectively measures methylation gains in somatic cells and may help assess the impact of anti-aging treatments across different tissues
Boosting longevity through dietary fibres: The role of β-glucan
β-glucan from plant-based fibres reduced fat, improved glucose tolerance, and boosted energy expenditure in high-fat diet mice, with positive shifts in gut microbiota and increased butyrate levels. Other fibres showed limited impact.
Blocking IL-11 to extend lifespan and reduce frailty in ageing
Blocking IL-11, a pro-inflammatory protein, extended lifespan and improved health in mice, reducing frailty and metabolic decline. Inhibiting IL-11 led to a lifespan increase of up to 25%, showing promise as a therapeutic target for enhancing human healthspan.
