Uridine rejuvenates aged hematopoietic stem cells in mice, enhancing blood cell function and countering age-related stem cell decline—an essential factor for promoting healthspan and longevity.
Extending longevity with mitochondrial and omega-3 support
Mitochondrial-targeted supplements like MitoQ, urolithin A, omega-3 fatty acids, and GlyNAC can enhance muscle health and physical function in ageing, potentially extending healthspan and promoting longevity.
Reversing age-related brain decline with OSKM gene therapy
OSKM gene therapy in the hippocampus rejuvenates cognitive function in aged rats, improving spatial memory and cognitive abilities without harmful effects. The treatment reverses age-related DNA methylation changes, suggesting potential for brain rejuvenation and delaying cognitive decline.
The power of breathwork for health and performance
Imagine having a powerful wellness tool with you every single day—one that’s as simple as breathing. Turns out, your breath holds far more potential than most people realise.
SIRT6’s role in slowing ageing and preventing diseases
SIRT6 regulates DNA repair and metabolic pathways, extending lifespan in mice by stabilising chromatin structure and preventing age-related diseases. This highlights potential therapeutic strategies for improving healthspan and longevity.
Tracking DNA methylation: A new biomarker for ageing
The PRC2-AgeIndex is a biomarker that tracks age-related changes in DNA methylation at specific sites linked to the Polycomb Repressive Complex 2 (PRC2). It effectively measures methylation gains in somatic cells and may help assess the impact of anti-aging treatments across different tissues
Boosting longevity through dietary fibres: The role of β-glucan
β-glucan from plant-based fibres reduced fat, improved glucose tolerance, and boosted energy expenditure in high-fat diet mice, with positive shifts in gut microbiota and increased butyrate levels. Other fibres showed limited impact.
Blocking IL-11 to extend lifespan and reduce frailty in ageing
Blocking IL-11, a pro-inflammatory protein, extended lifespan and improved health in mice, reducing frailty and metabolic decline. Inhibiting IL-11 led to a lifespan increase of up to 25%, showing promise as a therapeutic target for enhancing human healthspan.
The impact of hydrogen peroxide on cellular stress and longevity
Mitochondrial hydrogen peroxide (H2O2) doesn’t directly harm chromosomal DNA but plays a role in redox signalling, which helps regulate cellular responses to oxidative stress. This suggests that H2O2 has a more complex function in ageing, highlighting potential therapeutic strategies to reduce oxidative damage while maintaining its beneficial signalling effects.
Medicine 3.0 and functional medicine: How they overlap in Australia
Medicine 3.0 and functional medicine share a focus on personalised, preventative care aimed at optimising long-term health. At Melbourne Functional Medicine, this approach means addressing root causes, promoting longevity, and empowering patients to take charge of their wellbeing.
