Some longevity interventions compress the time spent in poor health by steepening the survival curve. These steepening strategies – unlike those that merely extend lifespan – can reduce relative sickspan, offering a route to longer and healthier lives.
Slower biological ageing linked to daily multivitamins
Daily multivitamin use slowed biological ageing by 10–20% over two years in older adults, as measured by advanced epigenetic clocks, suggesting a promising strategy to support healthy ageing when combined with good nutrition and lifestyle habits
Linking gut diversity and nutrient loss in Parkinson’s
Changes in gut bacteria in Parkinson’s disease are associated with lower production of key nutrients and anti-inflammatory compounds, suggesting gut-targeted strategies may help support brain health and slow disease progression.
Fat cells remember obesity even after weight loss
Adipose tissue retains an epigenetic ‘memory’ of obesity, even after substantial weight loss. These lasting changes impair fat cell function and heighten susceptibility to weight regain, potentially contributing to the ‘yo-yo’ effect. Targeting this memory could be key to achieving lasting metabolic health and improved longevity.
Hormesis: Using controlled stress to go harder, faster, stronger, smarter
Discover how small, controlled stressors like fasting, heat, cold, and low-oxygen training can trigger powerful adaptations in the body. Hormesis helps boost resilience, improve performance, sharpen cognition, and support healthy ageing – when done in the right dose.
Optimise your oral microbiome: Habits, products, breathing and more
Your oral microbiome does far more than protect your teeth – it influences immunity, inflammation, and whole-body health. Learn how to optimise it through smarter habits, better product choices, nasal breathing, and targeted strategies to reshape this vital ecosystem.
Torpor-like states reduce biological age in mice
Inducing a torpor-like state in mice significantly slowed blood epigenetic ageing and improved healthspan, revealing that a sustained drop in core body temperature, not calorie restriction or metabolic rate, is key to decelerating molecular ageing and promoting vitality.
Autophagy, mitochondria and mTOR: sulforaphane’s secret to healthy ageing
Sulforaphane triggers fasting-like responses in human cells, enhancing mitochondrial function, autophagy, and nutrient-sensing pathways, while suppressing glucose uptake and mTOR signalling—mimicking the benefits of caloric restriction.
Omega-3 slows biological ageing in older adults
Daily omega-3 slowed biological ageing over three years, with added benefits seen when combined with vitamin D and regular exercise in healthy older adults, based on DNA methylation clocks.
High-dose vitamin D boosts muscle over fat
High-dose vitamin D redirects surplus calories towards muscle growth and away from fat storage by modulating myostatin and leptin signalling. This promotes lean mass, strength, and linear growth without increasing overall weight, offering a new framework for enhancing body composition, energy balance, and metabolic health across the lifespan.
