Mitochondrial dysfunction is highlighted as a pivotal element in brain ageing and associated diseases, playing a significant role in energy shortages, elevated oxidative stress, and neuronal harm, driving the advancement of neurodegenerative conditions.
The science of fasting for healthier ageing
The study reveals that a 7-day complete caloric restriction triggers significant multi-organ proteome changes in humans, suggesting potential benefits for longevity and ageing.
Sleep enhances brain health and longevity
Neuronal activity boosts cerebrospinal fluid flow to remove brain waste during sleep, potentially affecting longevity and ageing.
Functional medicine health coaching improves diet compliance and health outcomes
Functional medicine health coaching significantly enhances adherence to elimination diets and improves self-reported health outcomes, as demonstrated in a randomised controlled trial.
IgG linked to ageing and metabolic decline
Immunoglobulin G (IgG) accelerates ageing by causing fibrosis in fat tissue, which leads to a decline in metabolic health, highlighting potential targets for anti-ageing treatments.
Red ginseng supports liver health and healthy ageing
Red Ginseng (RG) has been shown to improve insulin homeostasis and modulate cellular ageing processes in aged mice. It effectively reduces inflammation and cellular senescence in the liver, suggesting its potential as a beneficial supplement for ageing-related conditions.
Gut inflammation associated with ageing and Alzheimer’s risk
Higher gut inflammation levels are linked with ageing and Alzheimer’s disease, with elevated inflammation markers found in older individuals and those with Alzheimer’s, suggesting intestinal inflammation may contribute to the disease’s progression.
Brain health’s link to lymphatic drainage
Using fluorescent tracers in mice, researchers discovered that the nasopharyngeal lymphatic plexus is crucial for draining cerebrospinal fluid (CSF) to deep cervical lymph nodes. Unlike its downstream counterparts, this plexus lacks smooth muscle but has unique valves and structure. With age, it atrophies, although CSF drainage can still be enhanced through specific signalling pathways, suggesting potential treatments for age-related neurological conditions by improving CSF clearance.
Tackling age-related dental issues with RvE1
Resolvin E1 (RvE1) shows promise in dental pulp regeneration, enhancing Axin2-expressing cell proliferation and differentiation. It modulates inflammation, reduces infection severity, and prevents apical periodontitis, offering a new treatment approach for endodontic diseases.
Carrot compound isofalcarintriol enhances longevity
Isofalcarintriol, a polyacetylene found in carrots, promotes health and delays ageing. It activates defense mechanisms against oxidative stress, extends lifespan in worms, and in mice, improves glucose metabolism, enhances exercise capacity, and protects against age-related frailty. This compound works by inhibiting mitochondrial ATP synthase, triggering increased resistance to oxidative stress through NRF2 and AMPK pathway activation.
