Research
The latest insights on health and longevity
Slowing ageing with senolytics
Senolytic drugs dasatinib, quercetin, and fisetin may influence longevity and age-related decline by affecting DNA methylation clocks. February 2024 - Aging Key takeaways Dasatinib, quercetin, and fisetin's impact on ageing: These...
Exercise reduces heart risk: Gender matters
Physical activity significantly lowers the risk of death from all causes and cardiovascular diseases, with women experiencing greater benefits than men, underscoring its importance for longevity, especially in women. February 2024 - Journal of the...
IgG linked to ageing and metabolic decline
Immunoglobulin G (IgG) accelerates ageing by causing fibrosis in fat tissue, which leads to a decline in metabolic health, highlighting potential targets for anti-ageing treatments. February 2024 - Cell Metabolism Key takeaways ...
Fighting memory loss with KIBRA
KIBRA improves brain connectivity and memory, providing defense against memory decline linked to tauopathy, prevalent in neurodegenerative conditions. February 2024 - Journal of Clinical Investigation Key takeaways Enhanced synaptic...
Red ginseng supports liver health and healthy ageing
Red Ginseng (RG) has been shown to improve insulin homeostasis and modulate cellular ageing processes in aged mice. It effectively reduces inflammation and cellular senescence in the liver, suggesting its potential as a beneficial supplement for...
Senescent cells: Targeting with CAR T therapy
Senolytic CAR T cells targeting senescent cells rejuvenate metabolic function in old mice, with a single dose offering long-lasting preventive effects against age-related metabolic dysfunction, highlighting a promising approach for improving...
Gut inflammation associated with ageing and Alzheimer’s risk
Higher gut inflammation levels are linked with ageing and Alzheimer’s disease, with elevated inflammation markers found in older individuals and those with Alzheimer’s, suggesting intestinal inflammation may contribute to the disease’s progression....
Alzheimer’s risk in hormone therapy recipients
A small group of patients treated with contaminated cadaveric pituitary-derived growth hormone, containing amyloid-beta seeds, developed Alzheimer’s disease years later, highlighting a potential treatment-induced route of Alzheimer’s transmission...
New hope in Alzheimer’s through metabolic rescue
Aberrant protein S-nitrosylation in Alzheimer's disease inhibits the TCA cycle, causing synaptic loss due to compromised mitochondrial metabolism. Treatment with dimethyl succinate bypasses this block, partially restoring mitochondrial function and...
Brain health’s link to lymphatic drainage
Using fluorescent tracers in mice, researchers discovered that the nasopharyngeal lymphatic plexus is crucial for draining cerebrospinal fluid (CSF) to deep cervical lymph nodes. Unlike its downstream counterparts, this plexus lacks smooth muscle...