SCIENTIFIC RESEARCH

Trending insights on health and longevity

Our clinical team spends considerable time reading the latest research in the field of ageing and longevity. Because scientific papers can take time to digest, we’ve done the work for you. Search our database of summarised research below.

Ferroptosis and Cellular Senescence in Ageing and Wellness

Ferroptosis, a regulated form of cell death driven by iron-dependent lipid peroxidation, is intricately linked to aging and cellular senescence. Understanding and modulating ferroptosis may offer novel ways to address age-related diseases, improve healthspan, and promote longevity by reducing tissue dysfunction and enhancing overall well-being.

Benzyl butyl phthalate (BBP) exposure damages DNA and accelerates ageing

Benzyl butyl phthalate (BBP), a common plasticiser, disrupts reproductive health by increasing DNA damage and oxidative stress. Exposure impairs chromosome stability and gene expression, potentially affecting fertility and ageing. Findings highlight concerns about environmental toxins' impact on longevity and underscore the need for minimising exposure.

Machine learning designs gene regulators to slow ageing

Machine learning is used to design synthetic gene regulators that precisely target specific cell types, outperforming natural sequences. This could enable highly targeted therapies for ageing-related diseases, improving gene therapy precision and reducing off-target effects, potentially enhancing longevity by addressing cellular dysfunction more effectively.

Urolithin A boosts muscle strength and endurance in middle age

Urolithin A supplementation enhances muscle strength, aerobic endurance, and mitochondrial efficiency in middle-aged adults. It activates mitophagy, improves walking distance, and reduces inflammation markers, supporting muscle function and longevity. The findings highlight its potential as a nutritional intervention for healthy ageing​

DVE-1 and longevity regulation beyond mitochondrial stress

DVE-1 supports longevity in C. elegans through multiple pathways beyond its known role in mitochondrial stress response. It regulates lifespan independently of the mitochondrial unfolded protein response, influencing dietary restriction, germline signalling, and sensory perception. Its reduced nuclear presence in long-lived mutants suggests a broader cytosolic function in ageing.

The limits of human longevity in the twenty-first century

Radical human life extension is deemed unlikely this century. Since 1990, improvements in life expectancy have slowed, and reaching age 100 remains rare without breakthroughs in slowing biological ageing. Maximum lifespan is constrained by biological limits and diminishing returns on public health advancements

Genetic variability and the effects of dietary restriction on lifespan

Caloric restriction (20%-40%) and intermittent fasting enhanced lifespan in genetically diverse mice, with stronger effects tied to stricter calorie reduction. Lifespan varied with genetics and stress resilience, revealing healthspan and longevity are not always aligned. Extreme restrictions caused adverse effects, questioning optimal dietary strategies for ageing.

Urolithin A and its role in optimising ageing health

Urolithin A, derived from gut metabolism, enhances mitochondrial function, reduces inflammation, and improves muscle strength and endurance. It offers potential benefits for healthy ageing but does not affect body composition or overall physical function. Further research is needed to explore its impact on various systems and its long-term benefits.

Body roundness index as a tool for promoting healthy ageing

The Body Roundness Index (BRI) has a U-shaped relationship with all-cause mortality, with both very low and high BRI linked to higher death risk. BRI, which reflects visceral fat more accurately than BMI, may serve as a valuable, non-invasive tool for assessing health risks, aiding longevity-focused strategies.

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